Na titulní stránku Cevkoon Na titulní stránku IKEM
Oddělení experimentální
hypertenze a nefrologie
Oddělení experimentální
kardiologie
Oddělení experimentálního
výzkumu náhrad
orgánových funkcí




Publikace: r. 2011

Beneš J, Kazdová L, Drahota Z, Houštěk J, Medříková D, Kopecký J, Kovářová N, Vrbacký M, Sedmera D, Strnad H, Kolář M, Petrák J, Benada O, Škaroupková P, Červenka L, Melenovský V. Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats Clin. Sci. 121: 29-41, 2011.
Sporková A, Kopkan L, Vacarbová Š, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Červenka L. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure 2-kidney, 1-clip hypertensive rats. Am. J. Physiol. 300: R1468-R1475, 2011.
Melenovský V, Beneš J, Škaroupková P, Sedmera D, STrnad H, Kolář M, Vlček C, Petrák J, Beneš J, Papoušek F, Oliyarnyk O, Kazdová L, Červenka L. Metebolic characterization of volume overload heart failure due to aorto-caval fistula in rats. Mol. Cell. Biochem. 354: 83-96, 2011.
Honetschlagerová Z, Sporková A, Kopkan L, Husková Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Kujal P, Vernerová Z, Čertíková Chábová V, Tesař V, Červenka L. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. J Hypertens. 29: 1590-1601, 2011.

Publikace: r. 2006 - 2010

Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Clin Sci (Lond). 2010 Feb 23;118(10):617-32.
Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats. Walkowska A, Skaroupková P, Husková Z, Vanourková Z, Chábová VC, Tesar V, Kramer HJ, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Cervenka L. J Hypertens. 2010 Mar;28(3):582-93.
Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats. Husková Z, Vanourková Z, Erbanová M, Thumová M, Opocenský M, Mullins JJ, Kramer HJ, Bürgelová M, Cervenka L. J Hypertens. 2010 Mar;28(3):495-509.
Cholesterol induces renal vasoconstriction and anti-natriuresis by inhibiting nitric oxide production in anesthetized rats. Kopkan L, Khan MA, Lis A, Awayda MS, Majid DS. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1606-13. Epub 2009 Sep 23.
Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension. Bürgelová M, Vanourková Z, Thumová M, Dvorák P, Opocenský M, Kramer HJ, Zelízko M, Malý J, Bader M, Cervenka L. J Hypertens. 2009 Oct;27(10):1988-2000.PMID: 19593210
Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension. Vanourková Z, Kramer HJ, Erbanová M, Bäcker A, Cervenka L, Husková Z, Chábová VC, Tesar V, Dvorák P, Malý J, Vanecková I. Vascul Pharmacol. 2009 May-Jun;50(5-6):194-9.
Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats. Kopkan L, Husková Z, Vanourková Z, Thumová M, Skaroupková P, Malý J, Kramer HJ, Dvorák P, Cervenka L. Vascul Pharmacol. 2009 Aug-Sep;51(2-3):175-81. Epub 2009 Jun 16.
Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats. Erbanová M, Thumová M, Husková Z, Vanecková I, Vanourková Z, Mullins JJ, Kramer HJ, Bürgelová M, Rakusan D, Cervenka L. J Hypertens. 2009 Mar;27(3):575-86.
End-organ damage in hypertensive transgenic Ren-2 rats: influence of early and late endothelin receptor blockade. Vernerová Z, Kujal P, Kramer HJ, Bäcker A, Cervenka L, Vanecková I. Physiol Res. 2009;58 Suppl 2:S69-78. Review.
Renal interactions of renin-angiotensin system, nitric oxide and superoxide anion: implications in the pathophysiology of salt-sensitivity and hypertension. Kopkan L, Cervenka L. Physiol Res. 2009;58 Suppl 2:S55-67. Review.
[The role of arachidonic acid metabolites in the regulation of renal function and pathogenesis of hypertension] Certíková Chábová V. Cesk Fysiol. 2008;57(2-3):44-52. Review. Czech.
Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice. Cervenka L, Vanecková I, Husková Z, Vanourková Z, Erbanová M, Thumová M, Skaroupková P, Opocenský M, Malý J, Chábová VC, Tesar V, Bürgelová M, Viklický O, Teplan V, Zelízko M, Kramer HJ, Navar LG. J Hypertens. 2008 Jul;26(7):1379-89.
Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats. Vernerová Z, Kramer HJ, Bäcker A, Cervenka L, Opocenský M, Husková Z, Vanourková Z, Eis V, Chábová VC, Tesar V, Malý J, Vanecková I. Vascul Pharmacol. 2008 Apr-Jun;48(4-6):165-73. Epub 2008 Feb 12.
Superoxide and its interaction with nitric oxide modulates renal function in prehypertensive Ren-2 transgenic rats. Kopkan L, Husková Z, Vanourková Z, Thumová M, Skaroupková P, Cervenka L, Majid DS. J Hypertens. 2007 Nov;25(11):2257-65.
Nitric oxide and superoxide interactions in the kidney and their implication in the development of salt-sensitive hypertension. Majid DS, Kopkan L Clin Exp Pharmacol Physiol. 2007 Sep;34(9):946-52. Review.
The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats. Certíková Chábová V, Kramer HJ, Vanecková I, Thumová M, Skaroupková P, Tesar V, Falck JR, Imig JD, Cervenka L. Kidney Blood Press Res. 2007;30(5):335-46. Epub 2007 Aug 30.
Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats. Chábová VC, Kramer HJ, Vanecková I, Vernerová Z, Eis V, Tesar V, Skaroupková P, Thumová M, Schejbalová S, Husková Z, Vanourková Z, Kolský A, Imig JD, Cervenka L. Vascul Pharmacol. 2007 Aug-Sep;47(2-3):145-59. Epub 2007 Jun 2.
AT1 receptor antisense therapy transiently lowers blood pressure in Ren-2 transgenic rats. Vanecková I, Kopkan L, Husková Z, Vanourková Z, Schejbalová S, Cervenka L, Kramer HJ. Vascul Pharmacol. 2007 Jul;47(1):63-7. Epub 2007 Apr 21.
Effects of dietary salt load and salt depletion on the course of hypertension and angiotensin II levels in male and female heterozygous Ren-2 transgenic rats. Husková Z, Kramer H, Vanourková Z, Thumová M, Malý J, Opocenský M, Skaroupková P, Kolský A, Vernerová Z, Cervenka L. Kidney Blood Press Res. 2007;30(1):45-55. Epub 2007 Jan 25.
Long-term prevention of hypertension and end-organ damage in Ren-2 transgenic rats is achieved only with persistent but not transient AT1 receptor blockade. Vanecková I, Kopkan L, Husková Z, Vanourková Z, Schejbalová S, Cervenka L, Kramer HJ. Kidney Blood Press Res. 2007;30(1):38-44. Epub 2007 Jan 19.
[The renin-angiotensin system] Husková Z, Vanecková I, Cervenka L. Cesk Fysiol. 2006;55(4):138-47. Review. Czech.
AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension. Vanourková Z, Kramer HJ, Husková Z, Vanecková I, Opocenský M, Chábová VC, Tesar V, Skaroupková P, Thumová M, Dohnalová M, Mullins JJ, Cervenka L. J Hypertens. 2006 Dec;24(12):2465-72.
Late-onset endothelin-A receptor blockade reduces podocyte injury in homozygous Ren-2 rats despite severe hypertension. Opocenský M, Kramer HJ, Bäcker A, Vernerová Z, Eis V, Cervenka L, Certíková Chábová V, Tesar V, Vanecková I. Hypertension. 2006 Nov;48(5):965-71. Epub 2006 Oct 2.
Early-onset endothelin receptor blockade in hypertensive heterozygous Ren-2 rats. Vanecková I, Kramer HJ, Bäcker A, Schejbalová S, Vernerová Z, Eis V, Opocenský M, Dvorák P, Cervenka L. Vascul Pharmacol. 2006 Sep;45(3):163-70. Epub 2006 May 16.
Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats. Husková Z, Kramer HJ, Thumová M, Vanourková Z, Bürgelová M, Teplan V, Malý J, Cervenka L. Kidney Blood Press Res. 2006;29(2):74-83. Epub 2006 Apr 27.
Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic rats. Husková Z, Kramer HJ, Vanourková Z, Cervenka L. J Hypertens. 2006 Mar;24(3):517-27.
Enhanced superoxide activity modulates renal function in NO-deficient hypertensive rats. Kopkan L, Majid DS. Hypertension. 2006 Mar;47(3):568-72. Epub 2006 Jan 9.
na úvod

Publikace: r. 2001 - 2005

Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats. Kopkan L, Castillo A, Navar LG, Majid DS. Am J Physiol Renal Physiol. 2006 Jan;290(1):F80-6. Epub 2005 Aug 16.
Superoxide contributes to development of salt sensitivity and hypertension induced by nitric oxide deficiency. Kopkan L, Majid DS. Hypertension. 2005 Oct;46(4):1026-31. Epub 2005 Aug 15.
Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats. Vanecková I, Kramer HJ, Bäcker A, Vernerová Z, Opocensky M, Cervenka L. Hypertension. 2005 Oct;46(4):969-74. Epub 2005 Sep 12.
The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats. Kopkan L, Kramer HJ, Husková Z, Vanourková Z, Skaroupková P, Thurmová M, Cervenka L. J Hypertens. 2005 Aug;23(8):1531-9.
Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats. Vanecková I, Kramer HJ, Novotná J, Kazdová L, Opocenský M, Bader M, Ganten D, Cervenka L. Kidney Blood Press Res. 2005;28(2):117-26. Epub 2005 Mar 23.
Effects of angiotensin-(1-7) blockade on renal function in rats with enhanced intrarenal Ang II activity. Bürgelová M, Kramer HJ, Teplan V, Thumová M, Cervenka L. Kidney Int. 2005 Apr;67(4):1453-61.
Effects of sodium restriction and cyclooxygenase-2 inhibition on the course of hypertension, proteinuria and cardiac hypertrophy in Ren-2 transgenic rats. Vanecková I, Skaroupková P, Dvorák P, Certíková Chábová V, Tesar V, Bader M, Ganten D, Kramer HJ. Physiol Res. 2005;54(1):17-24
Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats. Opocenský M, Dvorák P, Malý J, Kramer HJ, Bäcker A, Kopkan L, Vernerová Z, Tesar V, Zima T, Bader M, Ganten D, Janda J, Vanecková I. Physiol Res. 2004;53(6):581-93.
Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats. Dvorák P, Kramer HJ, Bäcker A, Malý J, Kopkan L, Vanecková I, Vernerová Z, Opocenský M, Tesar V, Bader M, Ganten D, Janda J, Cervenka L. Kidney Blood Press Res. 2004;27(4):248-58. Epub 2004 Aug 2. Erratum in: Kidney Blood Press Res. 2005;28(1):19.
Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake. Vanecková I, Cahová M, Kramer HJ, Husková Z, Skaroupková P, Komers R, Bader M, Ganten D, Cervenka L. Kidney Blood Press Res. 2004;27(4):203-10. Epub 2004 Jul 20.
Plasma and kidney angiotensin II levels and renal functional responses to AT(1) receptor blockade in hypertensive Ren-2 transgenic rats. Kopkan L, Kramer HJ, Husková Z, Vanourková Z, Bäcker A, Bader M, Ganten D, Cervenka L. J Hypertens. 2004 Apr;22(4):819-25.
Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study. Kramer HJ, Horacek V, Bäcker A, Vaneckova I, Heller J. Kidney Blood Press Res. 2004;27(1):10-7. Epub 2003 Oct 28.
Genetic inactivation of the B2 receptor in mice worsens two-kidney, one-clip hypertension: role of NO and the AT2 receptor. Cervenka L, Vanecková I, Malý J, Horácek V, El-Dahr SS. J Hypertens. 2003 Aug;21(8):1531-8.
Role of nNOS in regulation of renal function in hypertensive Ren-2 transgenic rats. Cervenka L, Kramer HJ, Malý J, Vanecková I, Bäcker A, Bokemeyer D, Bader M, Ganten D, Mitchell KD. Physiol Res. 2002;51(6):571-80.
Lack of a role of neuronal nitric oxide synthase in the regulation of the renal function in rats fed a low-sodium diet. Vanecková I, Kramer HJ, Malý J, Bäcker A, Bokemeyer D, Cervenka L. Kidney Blood Press Res. 2002;25(4):224-31.
Intrarenal infusion of angiotensin-(1-7) modulates renal functional responses to exogenous angiotensin II in the rat. Bürgelová M, Kramer HJ, Teplan V, Velicková G, Vítko S, Heller J, Malý J, Cervenka L. Kidney Blood Press Res. 2002;25(4):202-10.
Essential role of AT1A receptor in the development of 2K1C hypertension. Cervenka L, Horácek V, Vanecková I, Hubácek JA, Oliverio MI, Coffman TM, Navar LG. Hypertension. 2002 Nov;40(5):735-41.
Role of nNOS in regulation of renal function in angiotensin II-induced hypertension. Cervenka L, Kramer HJ, Malý J, Heller J. Hypertension. 2001 Aug;38(2):280-5.
Angiotensin II-induced hypertension in bradykinin B2 receptor knockout mice. Cervenka L, Maly J, Karasová L, Simová M, Vítko S, Hellerová S, Heller J, El-Dahr SS. Hypertension. 2001 Mar;37(3):967-73.
na úvod

Publikace: r. 2000 a starší

[Experimental ischemic renal injury--effect of surgical technique and the protective effect of a nonpeptide angiotensin II antagonist (losartan)] Spatenka J, Havlícková J, Heller J, Cervenka L. Rozhl Chir. 2000 Aug;79(8):385-91. Czech.
[Role of the kidney in long-term regulation of blood pressure and the development of hypertension] Cervenka L, Símová M, Malý J, Heller J. Cesk Fysiol. 2000 Aug;49(3):116-33. Review. Czech.
Effect of intrarenal infusion of angiotensin-(1-7) in the dog. Heller J, Kramer HJ, Malý J, Cervenka L, Horácek V. Kidney Blood Press Res. 2000;23(2):89-94.
Renal responses to AT1 receptor blockade. Navar LG, Harrison-Bernard LM, Imig JD, Cervenka L, Mitchell KD. Am J Hypertens. 2000 Jan;13(1 Pt 2):45S-54S. Review.
Renal function in mice: effects of volume expansion and angiotensin II. Cervenka L, Mitchell KD, Navar LG. J Am Soc Nephrol. 1999 Dec;10(12):2631-6.
Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. Cervenka L, Mitchell KD, Oliverio MI, Coffman TM, Navar LG. Kidney Int. 1999 Nov;56(5):1855-62.
Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice. Cervenka L, Harrison-Bernard LM, Dipp S, Primrose G, Imig JD, El-Dahr SS. Hypertension. 1999 Aug;34(2):176-80.
[Discussion of the article by P. Dlouhý, M. Andĕl: Trans fatty acids in the diet and possible health risks. Cervenka L. Cas Lek Cesk. 1999 Jan 25;138(3):90-1. Czech. No abstract available.
Intrarenal angiotensin II generation and renal effects of AT1 receptor blockade. Navar LG, Harrison-Bernard LM, Imig JD, Wang CT, Cervenka L, Mitchell KD. J Am Soc Nephrol. 1999 Apr;10 Suppl 12:S266-72. Review.
Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats. Cervenka L, Wang CT, Mitchell KD, Navar LG. Hypertension. 1999 Jan;33(1):102-7.
Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan. Cervenka L, Navar LG. J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S197-201.
Concentrations and actions of intraluminal angiotensin II. Navar LG, Harrison-Bernard LM, Wang CT, Cervenka L, Mitchell KD. J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S189-95. Review.
Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats. Cervenka L, Wang CT, Navar LG. Am J Physiol. 1998 May;274(5 Pt 2):F940-5.
Losartan protects the rat kidney from ischemic injury. Heller J, Kramer HJ, Cervenka L, Hellerová S. Kidney Int Suppl. 1996 Jun;55:S113-4.
[Comparison of the effects of a low protein diet and angiotensin converting enzyme inhibitors on renal insufficiency in hypertensive rats] Cervenka L, Heller J. Cas Lek Cesk. 1996 May 15;135(10):305-7. Czech.
[The effect of electrostimulation with the Rebox apparatus on ischemic renal injury in rats] Janda J, Cervenka L, Spatenka J, Heller J, Slovák P. Cas Lek Cesk. 1996 Apr 17;135(8):252-4. Czech.
Comparison of the effects of a low-protein diet with the effects of a converting enzyme inhibitor on the progression of renal insufficiency in hypertensive rats. Cervenka L, Heller J. Ren Fail. 1996 Mar;18(2):173-80.
Lack of a beneficial effect of PD123319, an AT2-angiotensin receptor antagonist, on the course of ablation nephropathy in the rat. Cervenka L, Heller J, Jelínek F. Kidney Blood Press Res. 1996;19(5):241-4.
[Ineffectiveness of ACE inhibitors (enalapril) on glomerular damage in rats after a 5/6 nephrectomy and a high-salt diet] Cervenka L, Heller J, Hellerová S. Vnitr Lek. 1995 Apr;41(4):230-4. Czech.
[The effect of Tenziomin on function, morphology and lectin binding in rat kidney remnants after experimental subtotal nephrectomy] Jelínek F, Cervenka L, Heller J. Cesk Patol. 1995 Feb;31(1):21-7. Czech.
A comparison of the effect of feeding a low-protein diet and of pharmacological intervention on the course of ablation nephropathy in the rat. Cervenka L, Heller J. Ren Fail. 1995 Jan;17(1):27-35.
[The effect of a low-protein diet and certain pharmaceutical agents on the course of ablation nephropathy in rats] Heller J, Cervenka L, Hellerová S. Cas Lek Cesk. 1994 Jul 18;133(14):429-33. Czech.
na úvod

Přehled grantů na rok 2010

IGA - MZ
Číslo
IKEM
Číslo IGA - MZ Hlavní řešitel Název projektu Končí
154 NS/9699-4/2008 MVDr. Libor Kopkan, Ph.D. Úloha zvýšených koncentrací epoxyeikosatrienových kyselin v regulaci renálních funkcí a patofyziologii renovaskulární hypertenze 2011
155 NS/9703-4/2008 prof. MUDr. Luděk Červenka, CSc., MBA Nové farmakologické přístupy k léčbě hypertenze – kombinované zásahy do renin-angiotenzinového a endotelinového systému 2011
165 NS10499-3/2009 prof. MUDr. Luděk Červenka, CSc., MBA Úloha zhoršeného fungování tlakově-natriuretického mechanizmu ledvin v patofyziologii angiotenzin II dependentní maligní formy hypertenze 2011
166 NS10500-3/2009 MUDr. Věra Čertíková Chábová, Ph.D. Interakce renin-angiotenzinového a endotelinového systému v patofiziologii progrese renální insuficience a srdeční hypertrofie u hypertenzních potkanů 2011
AV ČR
Číslo
IKEM
Číslo IGA - MZ Hlavní řešitel Název projektu Končí
772 GA AV - KJB502030801 MVDr. Libor Kopkan, Ph.D. Úloha interakce mezi oxidem dusnatým, oxidativním stresem a renin-angiotenzinovým systémem v regulaci renálních funkcí a krevního tlaku u myší s deficientní endotheliální syntázou oxidu dusnatého s renovaskulární hypertenzí 2010
EU
Číslo
IKEM
Číslo IGA - MZ Hlavní řešitel Název projektu Končí
779 EU - 7. RP PIRG05-GA-2009-247847 Bc. Alexandra Sporková, Ph.D. Role of Expoxyeicosatrienoic Acids in the Regulation of Blood Pressure, Renal Hemodynamics and Sodium Excretion in Renovascular Model of Hypertension 30.9.2012
GAČR
Číslo
IKEM
Číslo IGA - MZ Hlavní řešitel Název projektu Končí
804 305/07/J004 RNDr. Ivana Vaněčková, CSc. Úloha renin-angiotenzinového a endotelinového systému v patofyziologii ANG II-dependentní hypertenze 30.6.2010
805 305/08/P053 Mgr. Zuzana Husková, Ph.D. Úloha RAAS v patofyziologii sůl-senzitivní hypertenze: studie na renin transgenních potkanech s indukovatelnou hypertenzí 2010
806 305/08/J006 prof. MUDr. Luděk Červenka, CSc., MBA Úloha zhoršené renální autoregulace a tkáňového renin-angiotenzinového systému v patofyziologii chronické renální insuficience 2010
812 P303/10/P170 Bc. Alexandra Sporková, Ph.D. Renální Autoregulace a Tlaková Natriuréza u Modelu Renovaskulární Hypertenze 2012
na úvod

Výzkumné záměry na rok 2010

Číslo
IKEM
Číslo IGA - MZ Hlavní řešitel Název projektu Končí
970 prof. MUDr. Luděk Červenka, CSc., MBA Úloha renin-angiontezinového systému v patofyziologii hypertenze a hypertenzního orgánového poškození 2011
975 Mgr. Zuzana Husková, Ph.D. Renální mechanizmus angiotenzin II-dependentní formy hypertenze 2011
997 MVDr. Libor Kopkan, Ph.D. Úloha epoxyeicosatrienových kyselin v patofyziologii angiotensin II dependentních forem hypertenze 2011
1017 Bc. Alexandra Sporková, Ph.D. Role of Expoxyeicosatrienoic Acids in the Regulation of Blood Pressure, Renal Hemodynamics and Sodium Excretion in Renovascular Model of Hypertension 2011
na úvod